Adverse Effects of Plant Food Supplements Self-Reported by Consumers in the PlantLIBRA Survey Involving Six European Countries
Identifieur interne : 000347 ( Main/Exploration ); précédent : 000346; suivant : 000348Adverse Effects of Plant Food Supplements Self-Reported by Consumers in the PlantLIBRA Survey Involving Six European Countries
Auteurs : Patrizia Restani [Italie] ; Chiara Di Lorenzo [Italie] ; Alicia Garcia-Alvarez [Espagne] ; Mihaela Badea [Roumanie] ; Alessandro Ceschi [Suisse] ; Bernadette Egan [Royaume-Uni] ; Lorena Dima [Roumanie] ; Saskia Lüde [Suisse] ; Franco M. Maggi [Italie] ; Angela Marculescu [Roumanie] ; Raimon Milà-Villarroel [Espagne] ; Monique M. Raats [Royaume-Uni] ; Lourdes Ribas-Barba [Espagne] ; Liisa Uusitalo [Finlande] ; Lluís Serra-Majem [Espagne]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
The use of food supplements containing botanicals is increasing in European markets. Although intended to maintain the health status, several cases of adverse effects to Plant Food Supplements (PFS) have been described.
To describe the self-reported adverse effects collected during the European PlantLIBRA PFS Consumer Survey 2011–2012, with a critical evaluation of the plausibility of the symptomatology reported using data from the literature and from the PlantLIBRA Poisons Centers' survey.
From the total sample of 2359 consumers involved in the consumers' survey, 82 subjects reported adverse effects due to a total of 87 PFS.
Cases were self-reported, therefore causality was not classified on the basis of clinical evidence, but by using the frequency/strength of adverse effects described in scientific papers: 52 out of 87 cases were defined as possible (59.8%) and 4 as probable (4.6%). Considering the most frequently cited botanicals, eight cases were due to
Comparing the data from this study with those published in scientific papers and obtained by the PlantLIBRA Poisons Centers' survey, some important conclusions can be drawn: severe adverse effects to PFS are quite rare, although mild or moderate adverse symptoms can be present. Data reported in this paper can help health professionals (and in particular family doctors) to become aware of possible new problems associated with the increasing use of food supplements containing botanicals.
Url:
DOI: 10.1371/journal.pone.0150089
PubMed: 26928206
PubMed Central: 4771165
Affiliations:
- Espagne, Finlande, Italie, Roumanie, Royaume-Uni, Suisse
- Canton de Zurich, Catalogne, Communauté de Madrid
- Barcelone, Madrid, Zurich
- Université de Zurich
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e Biomolecolari, Università degli Studi di Milano, Milano, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Di Lorenzo, Chiara" sort="Di Lorenzo, Chiara" uniqKey="Di Lorenzo C" first="Chiara" last="Di Lorenzo">Chiara Di Lorenzo</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Garcia Alvarez, Alicia" sort="Garcia Alvarez, Alicia" uniqKey="Garcia Alvarez A" first="Alicia" last="Garcia-Alvarez">Alicia Garcia-Alvarez</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Fundación para la Investigacion Nutricional, Barcelona Science Park, University of Barcelona, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación para la Investigacion Nutricional, Barcelona Science Park, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Badea, Mihaela" sort="Badea, Mihaela" uniqKey="Badea M" first="Mihaela" last="Badea">Mihaela Badea</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Transilvania University of Brasov, Brasov, Romania</addr-line></nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Transilvania University of Brasov, Brasov</wicri:regionArea><wicri:noRegion>Brasov</wicri:noRegion></affiliation></author><author><name sortKey="Ceschi, Alessandro" sort="Ceschi, Alessandro" uniqKey="Ceschi A" first="Alessandro" last="Ceschi">Alessandro Ceschi</name><affiliation wicri:level="4"><nlm:aff id="aff004"><addr-line>National Poisons Center, Tox Info Suisse, Associated Institute of the University of Zurich, Zurich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>National Poisons Center, Tox Info Suisse, Associated Institute of the University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, Ente Ospedaliero Cantonale, Lugano, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, Ente Ospedaliero Cantonale, Lugano</wicri:regionArea><wicri:noRegion>Lugano</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Egan, Bernadette" sort="Egan, Bernadette" uniqKey="Egan B" first="Bernadette" last="Egan">Bernadette Egan</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Food, Consumer Behaviour and Health Research Centre, University of Surrey, Guildford, Surrey, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Food, Consumer Behaviour and Health Research Centre, University of Surrey, Guildford, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Dima, Lorena" sort="Dima, Lorena" uniqKey="Dima L" first="Lorena" last="Dima">Lorena Dima</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Transilvania University of Brasov, Brasov, Romania</addr-line></nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Transilvania University of Brasov, Brasov</wicri:regionArea><wicri:noRegion>Brasov</wicri:noRegion></affiliation></author><author><name sortKey="Lude, Saskia" sort="Lude, Saskia" uniqKey="Lude S" first="Saskia" last="Lüde">Saskia Lüde</name><affiliation wicri:level="4"><nlm:aff id="aff004"><addr-line>National Poisons Center, Tox Info Suisse, Associated Institute of the University of Zurich, Zurich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>National Poisons Center, Tox Info Suisse, Associated Institute of the University of Zurich, Zurich</wicri:regionArea><orgName type="university">Université de Zurich</orgName><placeName><settlement type="city">Zurich</settlement><region nuts="3" type="region">Canton de Zurich</region></placeName></affiliation></author><author><name sortKey="Maggi, Franco M" sort="Maggi, Franco M" uniqKey="Maggi F" first="Franco M." last="Maggi">Franco M. Maggi</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Marculescu, Angela" sort="Marculescu, Angela" uniqKey="Marculescu A" first="Angela" last="Marculescu">Angela Marculescu</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Transilvania University of Brasov, Brasov, Romania</addr-line></nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Transilvania University of Brasov, Brasov</wicri:regionArea><wicri:noRegion>Brasov</wicri:noRegion></affiliation></author><author><name sortKey="Mila Villarroel, Raimon" sort="Mila Villarroel, Raimon" uniqKey="Mila Villarroel R" first="Raimon" last="Milà-Villarroel">Raimon Milà-Villarroel</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Fundación para la Investigacion Nutricional, Barcelona Science Park, University of Barcelona, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación para la Investigacion Nutricional, Barcelona Science Park, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Raats, Monique M" sort="Raats, Monique M" uniqKey="Raats M" first="Monique M." last="Raats">Monique M. Raats</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Food, Consumer Behaviour and Health Research Centre, University of Surrey, Guildford, Surrey, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Food, Consumer Behaviour and Health Research Centre, University of Surrey, Guildford, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Ribas Barba, Lourdes" sort="Ribas Barba, Lourdes" uniqKey="Ribas Barba L" first="Lourdes" last="Ribas-Barba">Lourdes Ribas-Barba</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Fundación para la Investigacion Nutricional, Barcelona Science Park, University of Barcelona, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación para la Investigacion Nutricional, Barcelona Science Park, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff009"><addr-line>Ciber Obn Fisiopatologıa de la Obesidad y la Nutrición, Instituto de Salud Carlos III, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Ciber Obn Fisiopatologıa de la Obesidad y la Nutrición, Instituto de Salud Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Uusitalo, Liisa" sort="Uusitalo, Liisa" uniqKey="Uusitalo L" first="Liisa" last="Uusitalo">Liisa Uusitalo</name><affiliation wicri:level="1"><nlm:aff id="aff008"><addr-line>Finnish Food Safety Authority Evira, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Food Safety Authority Evira, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Serra Majem, Lluis" sort="Serra Majem, Lluis" uniqKey="Serra Majem L" first="Lluís" last="Serra-Majem">Lluís Serra-Majem</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Fundación para la Investigacion Nutricional, Barcelona Science Park, University of Barcelona, Barcelona, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Fundación para la Investigacion Nutricional, Barcelona Science Park, University of Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff009"><addr-line>Ciber Obn Fisiopatologıa de la Obesidad y la Nutrición, Instituto de Salud Carlos III, Madrid, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Ciber Obn Fisiopatologıa de la Obesidad y la Nutrición, Instituto de Salud Carlos III, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff010"><addr-line>Institute of Biomedical and Health Research of Las Palmas, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain</addr-line></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Institute of Biomedical and Health Research of Las Palmas, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria</wicri:regionArea><wicri:noRegion>Las Palmas de Gran Canaria</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>The use of food supplements containing botanicals is increasing in European markets. Although intended to maintain the health status, several cases of adverse effects to Plant Food Supplements (PFS) have been described.</p></sec><sec id="sec002"><title>Objectives</title><p>To describe the self-reported adverse effects collected during the European PlantLIBRA PFS Consumer Survey 2011–2012, with a critical evaluation of the plausibility of the symptomatology reported using data from the literature and from the PlantLIBRA Poisons Centers' survey.</p></sec><sec id="sec003"><title>Subjects/Setting</title><p>From the total sample of 2359 consumers involved in the consumers' survey, 82 subjects reported adverse effects due to a total of 87 PFS.</p></sec><sec id="sec004"><title>Results</title><p>Cases were self-reported, therefore causality was not classified on the basis of clinical evidence, but by using the frequency/strength of adverse effects described in scientific papers: 52 out of 87 cases were defined as possible (59.8%) and 4 as probable (4.6%). Considering the most frequently cited botanicals, eight cases were due to <italic>Valeriana officinalis</italic> (garden valerian); seven to <italic>Camellia sinensis</italic> (tea); six to <italic>Ginkgo biloba</italic> (Maidenhair tree) and <italic>Paullinia cupana</italic> (guarana). Most adverse events related to the gastrointestinal tract, nervous and cardiovascular systems.</p></sec><sec id="sec005"><title>Conclusions</title><p>Comparing the data from this study with those published in scientific papers and obtained by the PlantLIBRA Poisons Centers' survey, some important conclusions can be drawn: severe adverse effects to PFS are quite rare, although mild or moderate adverse symptoms can be present. Data reported in this paper can help health professionals (and in particular family doctors) to become aware of possible new problems associated with the increasing use of food supplements containing botanicals.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Silano, V" uniqKey="Silano V">V Silano</name></author><author><name sortKey="Coppens, P" uniqKey="Coppens P">P Coppens</name></author><author><name sortKey="Larra Aga Guetaria, A" uniqKey="Larra Aga Guetaria A">A Larrañaga-Guetaria</name></author><author><name sortKey="Minghetti, P" uniqKey="Minghetti P">P Minghetti</name></author><author><name sortKey="Roth Ehrang, R" uniqKey="Roth Ehrang R">R Roth-Ehrang</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Skeie, G" uniqKey="Skeie G">G Skeie</name></author><author><name sortKey="Braaten, T" uniqKey="Braaten T">T 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sortKey="Smith, N" uniqKey="Smith N">N Smith</name></author><author><name sortKey="Atroch, Al" uniqKey="Atroch A">AL Atroch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kabalak, Aa" uniqKey="Kabalak A">AA Kabalak</name></author><author><name sortKey="Soyal, Ob" uniqKey="Soyal O">OB Soyal</name></author><author><name sortKey="Urfalioglu, A" uniqKey="Urfalioglu A">A Urfalioglu</name></author><author><name sortKey="Saracoglu, F" uniqKey="Saracoglu F">F Saracoglu</name></author><author><name sortKey="Gogus, N" uniqKey="Gogus N">N Gogus</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lonsdale, D" uniqKey="Lonsdale D">D Lonsdale</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lude, S" uniqKey="Lude S">S Lüde</name></author><author><name sortKey="Vecchio, S" uniqKey="Vecchio S">S Vecchio</name></author><author><name sortKey="Sinno Tellier, S" uniqKey="Sinno Tellier S">S Sinno-Tellier</name></author><author><name sortKey="Dopter, A" uniqKey="Dopter A">A Dopter</name></author><author><name sortKey="Mustonen, H" uniqKey="Mustonen H">H Mustonen</name></author><author><name sortKey="Vucinic, S" uniqKey="Vucinic S">S Vucinic</name></author><author><name sortKey="Jonsson, B" uniqKey="Jonsson B">B Jonsson</name></author><author><name sortKey="Muller, D" uniqKey="Muller D">D Müller</name></author><author><name sortKey="Fruchtengarten, L" uniqKey="Fruchtengarten L">L Fruchtengarten</name></author><author><name sortKey="Hruby, K" uniqKey="Hruby K">K Hruby</name></author><author><name sortKey="De Souza, Nascimento E" uniqKey="De Souza N">Nascimento E De Souza</name></author><author><name sortKey="Restani, P" uniqKey="Restani P">P Restani</name></author><author><name sortKey="Kupferschmidt, H" uniqKey="Kupferschmidt H">H Kupferschmidt</name></author><author><name sortKey="Ceschi, A" uniqKey="Ceschi A">A Ceschi</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Espagne</li><li>Finlande</li><li>Italie</li><li>Roumanie</li><li>Royaume-Uni</li><li>Suisse</li></country><region><li>Canton de Zurich</li><li>Catalogne</li><li>Communauté de Madrid</li></region><settlement><li>Barcelone</li><li>Madrid</li><li>Zurich</li></settlement><orgName><li>Université de Zurich</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Restani, Patrizia" sort="Restani, Patrizia" uniqKey="Restani P" first="Patrizia" last="Restani">Patrizia Restani</name></noRegion><name sortKey="Di Lorenzo, Chiara" sort="Di Lorenzo, Chiara" uniqKey="Di Lorenzo C" first="Chiara" last="Di Lorenzo">Chiara Di Lorenzo</name><name sortKey="Maggi, Franco M" sort="Maggi, Franco M" uniqKey="Maggi F" first="Franco M." last="Maggi">Franco M. Maggi</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Garcia Alvarez, Alicia" sort="Garcia Alvarez, Alicia" uniqKey="Garcia Alvarez A" first="Alicia" last="Garcia-Alvarez">Alicia Garcia-Alvarez</name></region><name sortKey="Mila Villarroel, Raimon" sort="Mila Villarroel, Raimon" uniqKey="Mila Villarroel R" first="Raimon" last="Milà-Villarroel">Raimon Milà-Villarroel</name><name sortKey="Ribas Barba, Lourdes" sort="Ribas Barba, Lourdes" uniqKey="Ribas Barba L" first="Lourdes" last="Ribas-Barba">Lourdes Ribas-Barba</name><name sortKey="Ribas Barba, Lourdes" sort="Ribas Barba, Lourdes" uniqKey="Ribas Barba L" first="Lourdes" last="Ribas-Barba">Lourdes Ribas-Barba</name><name sortKey="Serra Majem, Lluis" sort="Serra Majem, Lluis" uniqKey="Serra Majem L" first="Lluís" last="Serra-Majem">Lluís Serra-Majem</name><name sortKey="Serra Majem, Lluis" sort="Serra Majem, Lluis" uniqKey="Serra Majem L" first="Lluís" last="Serra-Majem">Lluís Serra-Majem</name><name sortKey="Serra Majem, Lluis" sort="Serra Majem, Lluis" uniqKey="Serra Majem L" first="Lluís" last="Serra-Majem">Lluís Serra-Majem</name></country><country name="Roumanie"><noRegion><name sortKey="Badea, Mihaela" sort="Badea, Mihaela" uniqKey="Badea M" first="Mihaela" last="Badea">Mihaela Badea</name></noRegion><name sortKey="Dima, Lorena" sort="Dima, Lorena" uniqKey="Dima L" first="Lorena" last="Dima">Lorena Dima</name><name sortKey="Marculescu, Angela" sort="Marculescu, Angela" uniqKey="Marculescu A" first="Angela" last="Marculescu">Angela Marculescu</name></country><country name="Suisse"><region name="Canton de Zurich"><name sortKey="Ceschi, Alessandro" sort="Ceschi, Alessandro" uniqKey="Ceschi A" first="Alessandro" last="Ceschi">Alessandro Ceschi</name></region><name sortKey="Ceschi, Alessandro" sort="Ceschi, Alessandro" uniqKey="Ceschi A" first="Alessandro" last="Ceschi">Alessandro Ceschi</name><name sortKey="Ceschi, Alessandro" sort="Ceschi, Alessandro" uniqKey="Ceschi A" first="Alessandro" last="Ceschi">Alessandro Ceschi</name><name sortKey="Lude, Saskia" sort="Lude, Saskia" uniqKey="Lude S" first="Saskia" last="Lüde">Saskia Lüde</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Egan, Bernadette" sort="Egan, Bernadette" uniqKey="Egan B" first="Bernadette" last="Egan">Bernadette Egan</name></noRegion><name sortKey="Raats, Monique M" sort="Raats, Monique M" uniqKey="Raats M" first="Monique M." last="Raats">Monique M. Raats</name></country><country name="Finlande"><noRegion><name sortKey="Uusitalo, Liisa" sort="Uusitalo, Liisa" uniqKey="Uusitalo L" first="Liisa" last="Uusitalo">Liisa Uusitalo</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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